Zyrtec (cetirizine) generally works faster than Claritin (loratadine) for most people. Cetirizine starts working within an hour, while loratadine can take 2-3 hours to reach full effect. However, Zyrtec is more likely to cause drowsiness than Claritin, though the newer formulations have reduced this side effect. If drowsiness is a major concern, Claritin might be a better first choice, but if you need rapid relief, Zyrtec is the way to go.